Riboflavin protect against lipopolysaccharide ‐induced shock via HSP25 in mice

Lipopolysaccharide-Induced Shock Apoptotic Cells Protect Mice against

Apoptotic cells protect mice against lipopolysaccharide-induced shock.

LPS is a main causative agent of septic shock. There is a lack of effective therapies. In vitro studies have shown that uptake of apoptotic cells actively inhibits the secretion by activated macrophages (Mphi) of proinflammatory mediators such as TNF-alpha and that such uptake increases the antiinflammatory and immunosuppressive cytokine TGF-beta. We therefore investigated the protective effect...

Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice

Background and purpose: Many herbs including Euphorbia have immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of the ethanolic extract of E.myrsinites. Materials and methods: In this experimental study, 40 Swiss albino male mice were randomly divided into 4 groups. Group A included healthy mice, group B was induced by lipopolysaccharide (LPS), grou...

The Novel Role of Platelet-Activating Factor in Protecting Mice against Lipopolysaccharide-Induced Endotoxic Shock

BACKGROUND Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock. Here we present novel activities for PAF in protecting mice against LPS-mediated endotoxic shock. PRINCIPAL FINDINGS In vivo PAF treatment immediately after LPS challenge markedly improved the survival rate against mortality from endotoxic shock. Admi...

Antibodies against CD14 protect primates from endotoxin-induced shock.

Lipopolysaccharide (LPS), residing in the outer membrane of all gram-negative bacteria, is considered a major initiating factor of the gram-negative septic shock syndrome in humans. LPS forms a complex with the LPS binding protein (LBP) in plasma, and LPS-LBP complexes engage a specific receptor, CD14, on the surface of myeloid cells, leading to the production of potent proinflammatory cytokine...